Quantum Flex
Quantum Flex
A cell expansion solution with low seeding requirements
The Quantum Flex system from Terumo Blood and Cell Technologies is a holistic, connected solution designed to meet your multiple cell culture bioreactor needs. Quantum Flex is suitable for a variety of cell types and applications and is scalable, reducing the need for multiple platforms.
This automated cell culture solution has minimal seeding requirements. And, using hollow-fiber perfusion technology, it can produce billions of suspension cells and hundreds of millions of adherent cells with a harvest volume of less than 1 L, simplifying downstream processing.
Integrated software assists with monitoring and process control and helps facilitate Good Manufacturing Practices (GMP) compliance.
Combined, these advantages — highlighted in the illustration — can also help reduce labor, costs, and open events.
Six key benefits of Quantum Flex:
- Scalability
- Connectivity
- Minimal seeding requirements
- Concentrated harvest volume
- cGMP compliance
- Adaptability
Flexible cell expansion for a wide variety of therapies
With flexibility and adaptability built into its innovative design, Quantum Flex fits into your process, regardless of what cell type you are working with or what type of therapy you are manufacturing. It provides a robust environment for both suspension cell culture (including T cell culture) and adherent cell culture (including mesenchymal stem cell culture). It accommodates a variety of starting material requirements and harvest needs, and it tolerates a range of common media and reagents.
Cell types and applications successfully performed on Quantum Flex
| Suspension Cell Expansion | Adherent Cell Expansion | Applications |
|---|---|---|
| T cells | Human pluripotent stem cells (ESCs, iPSCs) | Viral vector production using adherent and suspension HEK293 cells |
| Tregs | Mesenchymal stem cells (MSCs) | Exosome production |
| Tumor-infiltrating lymphocytes (TILs) | Fibroblasts | -- |
| CAR-T cells | Endothelial cells | -- |
| CD34+ cells | Neural stem cells (NSCs) | -- |
Cell manufacturing that scales as your therapy needs evolve and progress
As an automated, perfusion-based cell expansion system, Quantum Flex scales to fit your needs and adapts to your process as your therapy moves from process development to commercial production. Two sizes of hollow-fiber bioreactor allow you to transition between batch sizes on the same platform — so you can scale up or down as needed for each stage of your process, potentially saving time and money.
Streamlined path to GMP compliance
Quantum Flex and its integrated Cell Processing Application (CPA™) software can help you reduce the time, risk, and cost of compliance and data management
- Facilitation of cGMP compliance, including with FDA 21 CFR Part 211
- Maintain data integrity and facilitate compliance with FDA 21 CFR Part 11 and EU GMP Annex 11
- Provides a fully non-DEHP fluid path
- Barcode scanning to track material use and enforce rules
- User roles and authentication
- Comprehensive run reporting
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